Ingredient

Phytosphingosine

A naturally occurring lipid found in skin that supports ceramide production, fortifies the barrier, and provides antimicrobial benefits.

  • Best for

    Barrier Repair + Acne-Prone

  • Best to

    Restore + Balance + Soothe

  • Type

    Skin-Identical Sphingolipid

  • Use

    AM + PM

Phytosphingosine

What is it

What is Phytosphingosine?

Phytosphingosine is a sphingolipid found naturally in the skin, where it serves as a precursor to ceramides and plays an essential role in barrier function. It also has documented antimicrobial and anti-inflammatory properties, making it valuable in formulations targeting both barrier repair and skin clarity. It is skin-identical, meaning the body recognizes and uses it as a native component of the barrier.

MDAiRE ingredient benefits — nmf-hydrator

Benefits

What does Phytosphingosine do for your skin?

Phytosphingosine works on multiple fronts - supporting ceramide production, fortifying the barrier, calming inflammation, and helping regulate the skin's microbial balance. Key actions include:

  • Supports the skin's natural ceramide and barrier production
  • Calms inflammation and reduces redness
  • Provides antimicrobial support for clarity and balance
  • Reinforces skin resilience against environmental stressors
  • Compatible with sensitive, acne-prone, and reactive skin
MDAiRE ingredient how to_use — nmf-hydrator

How to use

How does Phytosphingosine fit your routine?

Phytosphingosine is typically found in barrier-focused moisturizers and serums for daily morning and evening use. No special application protocol is required.

Who should use it

Who should use Phytosphingosine?

Appropriate for all skin types. Particularly valuable for sensitive, acne-prone, reactive, or barrier-compromised skin. Well-tolerated and gentle with no known contraindications.

Formulated with

MDAiRE products formulated with Phytosphingosine

NMF Hydrator Barrier Repair on White Background

NMF Hydrator Barrier Repair

Multi-tasking daily hydrator formulated for all skin types. It strengthens the skin barrier, locks in balanced hydration, and...

From $52.00
(133)
Shop Now
Skincare Essentials Bundle featuring tall white Neck Tyte-R bottle with silver band highlighting advanced formula gallery 1

Neck Tyte-R

Clinical peptide focused formulation engineered specifically for the neck and decollete. Retinol, ceramides, peptides and brightening actives work...

From $50.00
(75)
Shop Now
Body Glow Duo Body Tyte tube with silver cap standing upright on pale gray background gallery position 1

Body Tyte

Revitalizing body lotion that brings the clinical standards of your facial skincare to the rest of your skin....

$89.00
(11)
Shop Now
NMF Intense Barrier Cream jar with metallic lid shown close-up in gallery position 1

NMF Intense Barrier Cream

Our richly restorative moisturizer for dry, mature, or treatment-stressed skin. Created to rebuild barrier integrity and deliver deep,...

$155.00
(28)
Shop Now

Not sure if this is right for you?

Let Dr. Kappel build your routine

Take the 1-minute skincare quiz and get a personalized product recommendation.

Start the Quiz